Welcome to the TwiCs network where we share information about the Trials within Cohorts (TwiCs) approach for designing and conducting practical randomised controlled trials.
The COVIDENCE UK Research Study was developed in response to the outbreak of coronavirus disease (COVID-19). This study uses the TwiCs design approach. This study was launched in 2020 and has already recruited a 'population based cohort of 25,000+ adults. This is providing a platform for multiple trials of interventions to prevent COVID related disease and improve health in the UK including the first COVIDENCE trial 'CORONAVIT' launched in October 2020.
HOT PRESS
Scoping review of randomised controlled trials conducted using cohorts Nickolls, et al
TwiCs based National platform for research into colon and rectal cancer in the Netherlands
Eight ongoing TwiCs based hospital based cancer cohorts in one hospital
First approved CTIMP using TwiCs design - ASSESS - meso led
Anna Bibby at Bristol University
CONSORT REPORTING GUIDELINES submitted for publication
Extension to Improve Reporting of Trials Using Observational Cohorts, Registries and Routinely Collected Health Data
(Funded by the Canadian Institutes of Health Research and the UK NIHR Clinical Trials Unit Support Funding)