Welcome to the TwiCs network where we share information about the Trials within Cohorts (TwiCs) approach for designing and conducting practical randomised controlled trials.
The COVIDENCE UK Research Study was developed in response to the outbreak of coronavirus disease (COVID-19). This study uses the TwiCs design approach. This study was launched in 2020 and has already recruited a 'population based cohort of 25,000+ adults. This is providing a platform for multiple trials of interventions to prevent COVID related disease and improve health in the UK including the first COVIDENCE trial 'CORONAVIT' launched in October 2020.
Anna Bibby at Bristol University
CONSORT REPORTING GUIDELINES submitted for publication
Extension to Improve Reporting of Trials Using Observational Cohorts, Registries and Routinely Collected Health Data
(Funded by the Canadian Institutes of Health Research and the UK NIHR Clinical Trials Unit Support Funding)